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Human papillomavirus (HPV) infection is the strongest risk number for opening cancer and is accepted as a causative broker of squamous cell carcinoma of the anus and its soul lesions.[1] Behaviors or scrutiny conditions that either indicate HPV infection or facilitate HPV infection or continuity are associated with increased risk; these add history of HPV-related cancers, high-risk unisexual practices such as sex betwixt men, receptive orifice coitus and numerous sexual partners, causal agency immunological disorder virus (HIV) infection, and chronic immunological disorder states.[2] Cigarette smoking is likewise a jeopardy factor.[3] supported on solid evidence, HPV infection causes squamous radiotelephone cancer of the anus. Magnitude of effect: around 90% of porta squamous animate thing cancers occur in individuals with noticeable HPV infection.[4] Of those, HPV strain 16 (HPV-16) and/or HPV-18 are noticeable in sir thomas more than 90% of cases.[4] Eighty-five percent of anal cancers feature squamous wireless telephone histology.[2] settled on homogeneous evidence, behaviors or medical conditions that either indicate HPV infection or facilitate HPV transmission or persistence change magnitude the probability or are associated with increased peril of anal cancer. Magnitude of effect: Risk varies by behavior and medical condition.

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